Alzheimer′s disease, anesthesia and the cholinergic system
نویسندگان
چکیده
منابع مشابه
Magnesium and Alzheimers Disease: The Cholinergic Hypothesis
The cholinergic deficit in Alzheimer’s disease (AD) remains the cornerstone for the understanding of chemical signal transfer. Hypofunctions of cholinergic systems are significantly involved in the signs and symptoms of senile dementia of the Alzheimer type. Cognitive deficits in AD have been widely associated with dysfunction of the cholinergic system. As a diagnostic marker of AD the activity...
متن کاملAlzheimer's Disease: Targeting the Cholinergic System
Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl-CoA and choline in the cytoplasm and the vesicular acetylcholine transporter (VAChT) uptakes the neurotransmitter into synaptic vesicles. Following depolarization, ACh undergoes exocytosis reaching the synaptic cleft, w...
متن کاملThe non-neuronal cholinergic system in health and disease.
Acetylcholine (ACh) is not only a neurotransmitter but is an ancient molecule that can be released by and act on non-neuronal cells. In these cells the system of ACh-synthesizing enzymes, transporters, receptors and degrading enzymes is termed the non-neuronal cholinergic system (NNCS). There is increasing evidence that the NNCS is dysregulated in various diseases and can have an influence on t...
متن کاملAlzheimer's disease and anaesthesia: implications for the central cholinergic system.
Alzheimer's disease (AD) is associated with a loss of cholinergic neurons resulting in profound memory disturbances and irreversible impairment of cognitive function. The central cholinergic system is involved in the action of general anaesthetic agents. Anaesthetic modulation of cholinergic transmission has profound effects on brain function via a cascade of synaptic and postsynaptic events by...
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ژورنال
عنوان ژورنال: Journal of Anaesthesiology Clinical Pharmacology
سال: 2011
ISSN: 0970-9185
DOI: 10.4103/0970-9185.81817